Published March 1, 1965
| Published
Journal Article
Open
A Comparison of the Initial Actions of Spleen Deoxyrihonuclease and Pancreatic Deoxyrihonuclease
- Creators
- Young, Elton T., II
- Sinsheimer, Robert L.
Abstract
The modes of action of several deoxyribonucleases have been studied in varying detail. The manner in which pancreatic deoxyribonuclease degrades deoxyribonucleic acid has been thoroughly analyzed both with regard to the breakdown of secondary structure and to the products formed. The activities of several other deoxyribonucleases have been characterized, especially those from Escherichia coli. A variety of specificities has been observed in which the preference seems to be most directly related to the secondary structure of the substrate and not rigorously to the internucleotide linkage.
Additional Information
© 1965 American Society for Biochemistry and Molecular Biology. Received for publication, September 2, 1964. These studies were supported in part by Grant RG6965 from the United States Public Health Service. Predoctoral fellow of the National Science Foundation during part of these studies. We would like to thank Dr. Jean Weigle for his help in the culture and assay of λ-phage.Attached Files
Published - J._Biol._Chem.-1965-Young-1274-80.pdf
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J._Biol._Chem.-1965-Young-1274-80.pdf
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Additional details
- Eprint ID
- 69268
- Resolver ID
- CaltechAUTHORS:20160728-080533751
- RG6965
- U.S. Public Health Service (USPHS)
- NSF Predoctoral Fellowship
- Created
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2016-07-28Created from EPrint's datestamp field
- Updated
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2019-10-03Created from EPrint's last_modified field