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Published January 1962 | public
Journal Article

The Synthesis of Ribosomes in E. coli. I. The Incorporation of C^(14)-Uracil into the Metabolic Pool and RNA

Abstract

C^(14)-uracil is rapidly incorporated by E. coli at low concentrations. Approximately half the radioactivity passes directly into RNA with very little delay. The remaining half enters a large metabolic pool and later is incorporated into RNA. The total rate of uptake (growing cells) is not greater than the requirement for uracil and cytosine for RNA synthesis. The size of the metabolic pool is not influenced measurably by the external uracil concentration. No evidence is found for the existence of a fraction of RNA which is rapidly synthesized and degraded.

Additional Information

© 1962 Biophysical Society. Received for publication, August 22, 1961.

Additional details

Created:
August 19, 2023
Modified:
October 20, 2023