Effects of Photoacoustic Imaging and Photothermal Ablation Therapy Mediated by Targeted Hollow Gold Nanospheres in an Orthotopic Mouse Xenograft Model of Glioma
Abstract
Advancements in nanotechnology have made it possible to create multifunctional nanostructures that can be used simultaneously to image and treat cancers. For example, hollow gold nanospheres (HAuNS) have been shown to generate intense photoacoustic signals and induce efficient photothermal ablation (PTA) therapy. In this study, we used photoacoustic tomography, a hybrid imaging modality, to assess the intravenous delivery of HAuNS targeted to integrins that are overexpressed in both glioma and angiogenic blood vessels in a mouse model of glioma. Mice were then treated with near-infrared laser, which elevated tumor temperature by 20.7°C. We found that PTA treatment significantly prolonged the survival of tumor-bearing mice. Taken together, these results show the feasibility of using a single nanostructure for image-guided local tumor PTA therapy with photoacoustic molecular imaging.
Additional Information
© 2011 by the American Association for Cancer Research. Received December 18, 2010; revised July 6, 2011; accepted August 8, 2011; published OnlineFirst August 19, 2011. We thank Stephanie Deming for editing the manuscript. This work was supported in part by grants from the NIH (grant R01 CA119387 05 S1 and MD Anderson Cancer Center Support Grant CA016672), the John S. Dunn Foundation, SPORE Head and Neck Career Development Award P50CA097007 (M.P. Melancon), and an Odyssey Fellowship (M.P. Melancon). Funding as an Odyssey Fellow is supported by the Odyssey Program and The Cockrell Foundation Award for Scientific Achievement at the University of Texas MD Anderson Cancer Center. The Cu-64 was provided by Washington University Medical School, which is partially funded by National Cancer Institute grant R24 CA86307. The costs of publication of this article were defrayed in part by the payment of page charges. This article must therefore be hereby marked advertisement in accordance with 18 U.S.C. Section 1734 solely to indicate this fact. No potential conflicts of interest were disclosed.Attached Files
Accepted Version - nihms-320253.pdf
Files
| Name | Size | Download all |
|---|---|---|
|
md5:505da6af69e8f29b6d617f3f79265461
|
1.5 MB | Preview Download |
Additional details
- PMCID
- PMC3185126
- Eprint ID
- 68910
- Resolver ID
- CaltechAUTHORS:20160708-083655411
- R01 CA119387 05 S1
- NIH
- CA016672
- NIH
- John S. Dunn Foundation
- P50CA097007
- NIH
- Odyssey Program
- University of Texas
- R24 CA86307
- National Cancer Institute
- Cockrell Foundation
- Created
-
2016-07-09Created from EPrint's datestamp field
- Updated
-
2021-11-11Created from EPrint's last_modified field