Published August 28, 1967
| public
Journal Article
Process of Infection with Bacteriophage øX174: XIV. Studies on Macromolecular Synthesis during Infection with a Lysis-defective Mutant
- Creators
- Lindqvist, Björn H.
- Sinsheimer, Robert L.
Abstract
Bacterial DNA, total RNA and protein synthesis have been studied in Escherichia coli C infected with a lysis-defective mutant of bacteriophage øX174. It has been found that host DNA synthesis ceases about 12 to 14 minutes after infection at 40°C, whereas RNA and protein synthesis continue throughout the infection. Host DNA synthesis does not stop when chloramphenicol (30 or 100 μg/ml.) is present before and during the infection. This result indicates that a phage-specific protein is responsible for the cessation of host DNA synthesis.
Additional Information
© 1967 Elsevier Ltd. Received 14 February 1967, and in revised form 19 May 1967. We acknowledge the excellent technical assistance of Miss Joan Dembrowski. The research was supported in part by U.S. Public Health Service research grant GM 13554.Additional details
- Eprint ID
- 68479
- Resolver ID
- CaltechAUTHORS:20160617-103601226
- GM 13554
- U.S. Public Health Service (USPHS)
- Created
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2016-06-17Created from EPrint's datestamp field
- Updated
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2021-11-11Created from EPrint's last_modified field