How inhibitory cues can both constrain and promote cell migration

Creators: Bronner, Marianne E.

Abstract

Collective cell migration is a common feature in both embryogenesis and metastasis. By coupling studies of neural crest migration in vivo and in vitro with mathematical modeling, Szabó et al. (2016, J. Cell Biol., http://dx.doi.org/10.1083/jcb.201602083) demonstrate that the proteoglycan versican forms a physical boundary that constrains neural crest cells to discrete streams, in turn facilitating their migration.

Additional Information

© 2016 Bronner. After the Initial Publication Period, RUP will grant to the public the non-exclusive right to copy, distribute, or display the Work under a Creative Commons Attribution-Noncommercial-Share Alike 3.0 Unpor ted license as described at http://creativecommons.org/licenses/by-nc-sa/3.0/ and http://creativecommons.org/licenses/by-nc-sa/3.0/legalcode. Submitted: 19 May 2016; Accepted: 20 May 2016. I thank Paige O'Connell for drawing Fig. 1. Work in the Bronner laboratory is supported by National Institutes of Health grants DE024157 and HD037105. The author declares no conflicting financial interests.

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