Published May 2016
| Published
Journal Article
Open
Phase-field model for collective cell migration
- Creators
- Najem, Sara
- Grant, Martin
Abstract
We construct a phase-field model for collective cell migration based on a Ginzburg-Landau free-energy formulation. We model adhesion, surface tension, repulsion, coattraction, and polarization, enabling us to follow the cells' morphologies and the effect of their membranes fluctuations on collective motion. We were able to measure the tissue surface tension as a function of the individual cell cortical tension and adhesion and identify a density threshold for cell-sheet formation.
Additional Information
© 2016 American Physical Society. Received 10 November 2015; published 9 May 2016. We acknowledge support from the Natural Sciences and Engineering Research Council of Canada, le Fonds de recherche du Québec—Nature et technologies, and discussions with Iain Couzin and members of the Couzin Lab at Princeton University.Attached Files
Published - PhysRevE.93.052405.pdf
Files
PhysRevE.93.052405.pdf
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Additional details
- Eprint ID
- 67347
- Resolver ID
- CaltechAUTHORS:20160525-105207767
- Natural Sciences and Engineering Research Council of Canada (NSERC)
- Fonds de recherche du Québec-Nature et Technologies (FRQ-NT)
- Created
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2016-05-26Created from EPrint's datestamp field
- Updated
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2021-11-11Created from EPrint's last_modified field