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Published June 1971 | public
Journal Article

Genetic expression in whole cells of heterozygous replicative-form molecules of Φ174

Abstract

The role of the parental viral strand in infection with bacteriophage Φ174 has been deduced from both biophysical and biological studies. The viral strand, on entering the cell, is converted to a double-stranded replicative form (RF). This parental RF is bound to the membrane, where the viral strand appears to be physically conserved throughout infection and to be required even at late times. In starved cells, only the RF containing the parental viral strand replicates, semiconservatively. The parental viral strand is conserved in this RF, with each new complementary partner being released in turn in a progeny RF molecule. The parental RF is also responsible for initial messenger RNA synthesis; it is not yet known whether or not it is responsible for all messenger RNA synthesis.

Additional Information

© 1971 Elsevier. Received 9 February 1971. This research was supported in part by a grant GM 13554 from the U.S. Public Health Service.

Additional details

Created:
August 19, 2023
Modified:
October 18, 2023