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Published 1987 | public
Book Section - Chapter

Synthetic sequence specific DNA binding molecules

Abstract

The design of sequence specific DNA-binding molecules has advanced in recent years due, in part, to the development of analytical techniques such as footprinting and affinity cleaving which allow rapid and precise analysis of hundreds of of potential DNA binding sites. The construction of synthetic molecules that bind in the minor and major groove of DNA with incrementally increasing sequence specificity is simply the first step toward developing a set of rules for the three-dimensional readout of double helical DNA.

Additional Information

© 1987 VCH. We are very grateful for the generous support of the National Institutes of Health, the American Cancer Society, the National Foundation for Cancer Research, the DARPA University Research Initiative Program, Burroughs-Wellcome Company, the Allied-Signal Corporation and the Smith Kline Beckman Corporation.

Additional details

Created:
August 19, 2023
Modified:
October 18, 2023