Oligonucleotide recognition of double-helical DNA by triple-helix formation
- Creators
-
Dervan, Peter B.
- Other:
- Cohen, Jack S.
Abstract
The sequence-specific recognition of double-helical DNA is an essential biological process responsible for the regulation of cellular functions including transcription, replication and cell division. The ability to design synthetic molecules that bind sequence-specifically to unique sites on human DNA has major implications for the treatment of genetic, oncogenic and viral diseases. A detailed understanding of the chemical principles for binding specific sites on double-helical DNA with oligodeoxynucleotides (or their analogues) by triple-strand formation would provide a pivotal first step in the development of a novel chemotherapeutic strategy of genetic targeting. This could ultimately enable precise inactivation of undesirable DNA sequences within the human genome.
Additional Information
© 1989 CRC Press. We are grateful to the National Institutes of Health and the Office of Naval Research for generous grant support. In addition, unrestricted funds from Burroughs Wellcome, Merck, Hoffmann-La Roche and the Parsons Foundation are gratefully acknowledged.Additional details
- Eprint ID
- 67184
- Resolver ID
- CaltechAUTHORS:20160519-124134048
- NIH
- Office of Naval Research (ONR)
- Burroughs-Wellcome
- Merck
- Hoffmann-La Roche
- Ralph M. Parsons Foundation
- Created
-
2016-05-20Created from EPrint's datestamp field
- Updated
-
2021-11-11Created from EPrint's last_modified field
- Series Name
- Topics in molecular and structural biology
- Series Volume or Issue Number
- 12