Published April 1, 1993
| public
Journal Article
Antiparallel side-by-side heterodimer for sequence-specific recognition in the minor groove of DNA by a distamycin/1-methylimidazole-2-carboxamide-netropsin pair
- Creators
- Mrksich, Milan
-
Dervan, Peter B.
Abstract
The two peptides distamycin A(D) and 1-methylimidazole-2-carboxamide-netropsin (2-ImN) simultaneously bind the five-base-pair sequence 5'-TGTTA-3'. Footprinting experiments indicate that both molecules are necessary for binding to this sequence while affinity cleaving data define the orientations with which each peptide binds to this sequence. The footprinting and affinity cleaving data are consistent with a model wherein the two peptides bind as a side-by-side antiparallel heterodimer in the minor groove of double-helical DNA.
Additional Information
© 1993 American Chemical Society. Publication Date: April 1993. We are grateful to the National Institutes of Health (Grant GM-27681) and Burroughs Wellcome for research support, and for a National Institutes of Health Research Service Award to M.M.Additional details
- Eprint ID
- 66926
- Resolver ID
- CaltechAUTHORS:20160510-135929277
- GM-27681
- NIH
- Burroughs Wellcome Fund
- NIH Predoctoral Fellowship
- Created
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2016-05-17Created from EPrint's datestamp field
- Updated
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2021-11-11Created from EPrint's last_modified field