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Published July 1996 | public
Journal Article

Sequence-specific recognition of DNA by a major and minor groove binding ligand

Abstract

A combination of the binding models for the simultaneous recognition of both grooves of DNA led to the design of a polyamide–oligonucleotide ligand that binds to a specific DNA sequence with an association constant of K_a > 2 × 10^(10) M^(−1). The oligonucleotide portion forms a triple helix in the major groove of DNA, and the polyamide unit forms a hairpin in the minor groove (see ribbon model below).

Additional Information

© 1996 VCH Verlagsgesellschuft mbH. Received: March 3. 1996. We are grateful to the National Institutes of Health for support (GM-27681) and to the Howard Hughes Medical Institute for a Predoctoral Fellowship to E. E. B.

Additional details

Created:
August 22, 2023
Modified:
October 18, 2023