Published June 5, 1998
| public
Journal Article
Cooperative hairpin dimers for recognition of DNA by pyrrole-imidazole polyamides
Abstract
A doubling of the length of binding site for the same size of ligand is achieved by the title compound by formation of a cooperative hairpin dimer on binding to DNA (depicted schematically below). The binding affinity and selectivity are unaffected by this new binding pattern. Circles represent heterocyclic rings, and diamonds and curved lines represent β-alanine and (R)-2,4-diaminobutyric acid residues, respectively.
Additional Information
© 1998 Wiley-VCH Verlag GmbH, D-69451 Weinheim. Received: January 8, 1998. We are grateful to the National Institutes of Health for support (GM-27681), to the National Science Foundation and the Ralph M. Parsons Foundation for predoctoral fellowships to J.W.T., and to the Howard Hughes Medical Institute for a predoctoral fellowship to E.E.B. Supporting information for this article is available on the WWW under http://www.wiley-vch.de/home/angewandte/ or from the author.Additional details
- Eprint ID
- 66863
- Resolver ID
- CaltechAUTHORS:20160510-093706312
- GM-27681
- NIH
- NSF Predoctoral Fellowship
- Ralph M. Parsons Foundation
- Howard Hughes Medical Institute (HHMI)
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2016-05-11Created from EPrint's datestamp field
- Updated
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2021-11-11Created from EPrint's last_modified field