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Published July 21, 2003 | public
Journal Article

U-pin polyamide motif for recognition of the DNA minor groove

Abstract

DNA-binding hairpin pyrrole-imidazole polyamides with gamma-aminobutyric acid as a turn-forming residue tolerate A.T or T.A base pairs under the turn. U-pins-polyamides with a different turn-have been synthesized and their DNA binding properties were studied. The two turn-forming residues are connected via the ring nitrogens using variable length aliphatic linkers ((CH(2))(n), n=3-6). Through optimization of the linker length and the substituents at the 2-position of the pyrrole residue on the U-turn, polyamides with G.C/C.G tolerant turns could be found, which bind to DNA in a predictable manner.

Additional Information

© 2003 WILEY-VCH. Received: January 29, 2003. We are grateful to the National Institutes of Health for research support, to the Alexander von Humboldt-Foundation (Germany) for a Feodor Lynen Fellowship for A.H. and to Dr. Bogdan Olenyuk for helpful discussions.

Additional details

Created:
August 22, 2023
Modified:
October 18, 2023