Published January 27, 2005
| public
Book Section - Chapter
Regulation of gene expression by synthetic DNA-binding ligands
Abstract
During the past 20 years, polyamides have evolved from the natural product distamycin to a new class of programmable heterocyclic oligomers that bind a broad repertoire of DNA sequences with high affinity and specificity. This chapter details recent advances in this field of research, focusing on molecular recognition of DNA, and biological applications such as modulating gene expression by small molecules. Work presented here represents efforts towards the modulation of specific cellular function by small molecules in an addressable fashion within the context of live cells.
Additional Information
© 2005 Springer. We are grateful to the National Institutes of Health for research support. A.T.P.-K. is supported by an NIH Predoctoral Training Grant. E.J.F. is supported by an NIH Research Service Award and Ralph M. Parsons Fellowship. B.S.E. is supported by a predoctoral fellowship from the Howard Hughes Medical Institute.Additional details
- Eprint ID
- 66762
- DOI
- 10.1007/b100440
- Resolver ID
- CaltechAUTHORS:20160509-112818968
- NIH Predoctoral Fellowship
- Ralph M. Parsons Foundation
- Howard Hughes Medical Institute (HHMI)
- Created
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2016-05-17Created from EPrint's datestamp field
- Updated
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2021-11-11Created from EPrint's last_modified field
- Series Name
- Topics in Current Chemistry
- Series Volume or Issue Number
- 253