Leukemia Inhibitory Factor Is an Anti-Inflammatory and Analgesic Cytokine

Creators: Banner, Lisa R.; Patterson, Paul H.; Allchorne, Andrew; Poole, Steve; Woolf, Clifford J.

Abstract

The mRNA for leukemia inhibitory factor (LIF), a neuroimmune signaling molecule, is elevated during skin inflammation produced by intraplantar injection of complete Freund's adjuvant (CFA). Moreover, although LIF knock-out mice display normal sensitivity to cutaneous mechanical and thermal stimulation compared with wild-type mice, the degree of CFA-induced inflammation in mice lacking LIF is enhanced in spatial extent, amplitude, cellular infiltrate, and interleukin (IL)-1β and nerve growth factor (NGF) expression. Conversely, local injection of low doses of recombinant LIF diminishes mechanical and thermal hypersensitivity as well as the IL-1β and NGF expression induced by CFA. These data show that upregulation of LIF during peripheral inflammation serves a key, early anti-inflammatory role and that exogenous LIF can reduce inflammatory hyperalgesia.

Additional Information

© 1998 Society for Neuroscience. Beginning six months after publication the Work will be made freely available to the public on SfN's website to copy, distribute, or display under a Creative Commons Attribution 4.0 International (CC BY 4.0) license (https://creativecommons.org/licenses/by/4.0/). Received Nov. 20, 1997; revised April 10, 1998; accepted April 28, 1998. This work was supported by the Medical Research Council (C.J.W.), the Wellcome Trust (C.J.W.), the Human Frontiers Science Program (C.J.W.), the National Institutes of Health National Research Service Award (L.R.B.), and the National Institute of Neurological Diseases and Stroke (P.H.P.).

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