Published August 22, 2003
| public
Journal Article
Long-Range DNA Charge Transport
- Creators
- Delaney, Sarah
-
Barton, Jacqueline K.
Abstract
The stack of base pairs within double helical DNA has been shown to mediate charge transport reactions. Charge transport through DNA can result in chemistry at a distance, yielding oxidative DNA damage at a site remote from the bound oxidant. Since DNA charge transport chemistry depends on coupling within the stacked base pair array, this chemistry is remarkably sensitive to sequence-dependent DNA structure and dynamics. Here, we discuss different features of DNA charge transport chemistry, including applications as well as possible biological consequences and opportunities.
Additional Information
© 2003 American Chemical Society. Received March 17, 2003. Publication Date (Web): August 15, 2003. We are grateful to the NIH for financial support and to our many co-workers and collaborators for their contributions. J.K.B. also thanks the colleagues she has had who helped to inspire the exploration of this chemistry.Additional details
- Eprint ID
- 64813
- DOI
- 10.1021/jo030095y
- Resolver ID
- CaltechAUTHORS:20160226-135927857
- NIH
- Created
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2016-02-29Created from EPrint's datestamp field
- Updated
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2021-11-10Created from EPrint's last_modified field