Lanthanides: Applications in Cancer Diagnosis and Therapy
- Creators
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Teo, Ruijie D.
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Termini, John
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Gray, Harry B.
Abstract
Lanthanide complexes are of increasing importance in cancer diagnosis and therapy, owing to the versatile chemical and magnetic properties of the lanthanide-ion 4f electronic configuration. Following the first implementation of gadolinium(III)-based contrast agents in magnetic resonance imaging in the 1980s, lanthanide-based small molecules and nanomaterials have been investigated as cytotoxic agents and inhibitors, in photodynamic therapy, radiation therapy, drug/gene delivery, biosensing, and bioimaging. As the potential utility of lanthanides in these areas continues to increase, this timely review of current applications will be useful to medicinal chemists and other investigators interested in the latest developments and trends in this emerging field.
Additional Information
© 2016 American Chemical Society. Received: December 21, 2015. Publication Date (Web): February 10, 2016. This work was supported by the Caltech-City of Hope Biomedical Research Initiative (J.T. and H.B.G.) and the AACR Thomas J. Bardos Science Education Award (R.D.T.). Support from NIH Grant R01 DK019038 (H.B.G.) and NIH Grant R01 CA176611 (J.T.) also is acknowledged. The authors declare no competing financial interest.Attached Files
Accepted Version - nihms-760310.pdf
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Additional details
- PMCID
- PMC4945403
- Eprint ID
- 64631
- Resolver ID
- CaltechAUTHORS:20160222-104525554
- Caltech-City of Hope Biomedical Initiative
- American Association for Cancer Research (AACR)
- R01 DK019038
- NIH
- R01 CA176611
- NIH
- Created
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2016-02-22Created from EPrint's datestamp field
- Updated
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2022-05-06Created from EPrint's last_modified field