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Published August 2007 | Accepted Version
Journal Article Open

Logic of gene regulatory networks

Abstract

Regulatory networks of transcription factors and signaling molecules lie at the heart of development. Their architecture implements logic functions whose execution propels cells from one regulatory state to the next, thus driving development forward. As an example of a subcircuit that translates transcriptional input into developmental output, we consider a particularly simple case, the regulatory processes underlying pigment cell formation in sea urchin embryos. The regulatory events in this process can be represented as elementary logic functions.

Additional Information

© 2007 Elsevier Ltd. Available online 6th August 2007. We would like to thank Andy Ransick, Jongmin Nam and Smadar Ben-Tabou de-Leon for helpful discussions. Research was supported by NIH grant HD-37105.

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