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Published August 2003 | public
Journal Article

The year(s) of the contrast agent – micro-MRI in the new millennium

Abstract

The beginning of the new millennium has been a dynamic time for the field of magnetic resonance imaging (MRI). Exciting recent advances have been made at all levels of imaging, ranging from the visualization of single cells to rodents, birds and the human brain. Many of these techniques employ contrast agents to visualize the movement or activity of cells or organs in vivo; examples of this include the observation of stem cell migration, the tracking of labeled T cells, and the visualization of the events of gastrulation in developing Xenopus embryos. Other advances include improved techniques for elucidating white matter tracts in brain by either monitoring the diffusion of water along the tracts or tracing active neuronal tracts in vivo with Mn^(2+) ions. Imaging of the immune system presents two dramatically different challenges: imaging most if not all of the body to follow cell trafficking, and imaging at cellular resolution to follow key intercellular and intracellular events.

Additional Information

© 2003 Elsevier Science Ltd. The authors gratefully acknowledge Mathias Höhn, Annemie Van der Linden, Cyrus Papan, Richard Sidman, Susumu Mori and Jiangyang Zhang for their contribution of figures for this review. Additionally, Helen McBride, R Jacobs, Rita Schack and T Pautler are gratefully acknowledged for discussions, suggestions and support.

Additional details

Created:
August 19, 2023
Modified:
October 17, 2023