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Published July 1, 2004 | public
Journal Article

cis-Regulatory control circuits in development

Abstract

During development, an organism undergoes many rounds of pattern formation, generating ever-greater complexity with each ensuing round of cell division and specification. The instructions for executing this process are encoded in the cis-regulatory modules that direct the expression of developmental transcription factors and signaling molecules. Each transcription factor binding site within a cis-regulatory module contributes information about when, where, or how much a gene is turned on, and by dissecting the modules driving a given gene, all the inputs governing expression of the gene can be accurately identified. Furthermore, by mapping the output of each gene to the inputs of other genes, it is possible to reverse engineer developmental circuits and even whole networks. At this higher level of organization, common bilaterian strategies for specifying progenitor fields, locking down regulatory states, and driving development forward emerge.

Additional Information

© 2004 Elsevier Inc. Received for publication 20 January 2004, revised 20 March 2004, accepted 20 March 2004. Available online 10 May 2004. Research was supported by NIH grants HD37105, GM61005, RR06591, and RR15044; the Office of Science (BER), U.S. Department of Energy, grant DE-FG02-03ER63584. The Caltech Beckman Institute; and Lucille P. Markey Charitable Trust.

Additional details

Created:
August 22, 2023
Modified:
October 23, 2023