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Published November 10, 1977 | public
Journal Article

Neurotransmitter synthesis and uptake by isolated sympathetic neurones in microcultures

Abstract

Assays of isolated single sympathetic neurones show that their transmitter functions can be either adrenergic or cholinergic depending on growth conditions. The data suggest that the number of transmitters made by most mature individual neurones is restricted.

Additional Information

© 1977 Nature Publishing Group. Received 31 May accepted 15 August 1977. We thank Drs Linda Chun, Philippa Claude, Edwin Furshpan, and David Potter for suggestions and for reagents, and Karen Fischer and Doreen McDowell for their aid in maintaining cultures. This work was supported by a Grant-in-Aid (93-877) from the American and Massachusetts Heart Associations and a USPHS grant (l ROI NS 11028) from the National Institute of Neurological and Communicable iseases and Stroke. P.H.P. is a Research Career Development Awardee of the NINCDS (I K04 NS70806) and L.F.R. was supported by fellowships from the Jane Coffin Childs Foundation, the Medical Foundation, and NINCDS.

Additional details

Created:
August 19, 2023
Modified:
October 17, 2023