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Published 1977 | public
Book Section - Chapter

The role of non-neuronal cells in the development of sympathetically derived neurons

Abstract

As other speakers in this session have discussed, a variety of influences are brought to bear on presumptive sympathetic neurons during their migration and subsequent differentiation. Some of these other influences, namely nerve growth factor (NGF) and electrical activity, continue to affect the functional state of these neurons even in the adult. These studies have involved axotomy, decentralization, transplantation in embryos, or explantation to the anterior chamber of the eye, to the chorioallantoic membrane, or to organ culture. Yet another approach has been to dissociate the neurons and grow them in cell culture. Investigation of their development in the absence of other cell types or in the presence of added cells of known origin then contributed information about the relative importance of such cellular influences as well as their mechanism of action. The potential for controlling the fluid environment as well as the substratum on which the cells are grown may also be exploited to yield information about normal development.

Additional Information

© 1977 Alan R. Liss, Inc. It is a pleasure to acknowledge the able assistance of Doreen McDowell, Karen Fischer, and Kathy Birmingham with the culturing. We also thank Eleanor P. Livingston and Joe Gagliardi for excellent help with the manuscript. This work was supported by an American Heart Association Grant-in-Aid (73-877) and a United States Public Health Service Grant (1 RO1 NS 11027) from the National Institute of Neurological and Communicable Diseases and Stroke. Paul H. Patterson is a Research Career Development Awardee of the N.I.N.C.D.S. (1 K04 NS 70806); Louis F. Reichardt has been a postdoctoral fellow of the N.I.N.C.D.S. (1 F22 NS 01784), Jane Coffin Childs Memorial Fund for Medical Research, and the Medical Foundation; and Linda L. Y. Chun is a Public Health Service Trainee (TO1 NS 05731).

Additional details

Created:
August 19, 2023
Modified:
January 13, 2024