Inhibition of Photoperiodic Induction by 5-Fluorouracil
- Creators
- Salisbury, Frank B.
- Bonner, James
Abstract
In this paper it will be shown that photoperiodic induction of the cocklebur, a short day plant, is inhibited by the pyrimidine 5-fluorouracil ( 5-FU). The studies of other workers have shown that 5-FU inhibits the growth of various kinds of cells and tissues by suppressing the formation of thymidine, and that application of thymidine relieves the inhibitory effects of 5-FU. In these cases 5-FU is an inhibitor of DNA synthesis (2, 4, 5). In other cases, however, 5-FU inhibits RNA synthesis. Thus 5-FU inhibits the production of tobacco mosaic viral RNA by tobacco leaves ( 1). This inhibition, which is relieved neither by thymidine nor by uracil, is associated with incorporation of 5-FU into the viral RNA (3). In. hibition of photoperiodic induction by 5-FU is not reversed by either thymidine or uracil but is reversed by orotic acid (6) which is known to be an intermediate in the biogenesis both of uridine and cytidine and of deoxycytidine and thymidine. Reversal of 5-FU inhibition by orotic acid suggests the hypothesis that the inhibition is related in some way to suppression of nucleic acid metabolism.
Additional Information
© 1960 American Society of Plant Biologists. Received June 3, 1959. Supported in part by grants from the Frasch Foundation, National Science Foundation, and the Colorado State University Research Foundation. This work was reported at the Annual Meeting, American Society of Plant Physiologists, Indiana University. August, 1958. The authors gratefully acknowledge the able technical assistance of Pauline Christiansen.Attached Files
Published - 4259557.pdf
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Additional details
- PMCID
- PMC405938
- Eprint ID
- 62770
- Resolver ID
- CaltechAUTHORS:20151210-083053064
- Frasch Foundation
- NSF
- Colorado State University Research Foundation
- Created
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2015-12-10Created from EPrint's datestamp field
- Updated
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2021-11-10Created from EPrint's last_modified field