Histone Biology and Chemistry

Abstract

Recent advances in the biophysics and biochemistry of the nucleic acids have clearly shown that these are the molecules entrusted by nature with the task of storage and transfer of genetic information. Rapid developments in the status of the coding problem provide us with the promise that the day is near when we shall have full understanding of the genetic language. Attention is gradually being focused upon the mechanisms which control the transcription of the genetic message, and which, by the exertion of such control, bring about organized biological activity of the cell and orderly development of a single cell into a multicellular organism. What substances in the cell could be expected to serve in the control of genetic activity; to program the transcription and expression of the genetic language?

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