Published September 1, 1982
| public
Journal Article
Studies of the binding interactions of cis-diamminedichloroplatinum(II) with amines and nucleosides by nitrogen-15 nuclear magnetic resonance
- Creators
- Nee, Michael
- Roberts, John D.
Abstract
The ^(15)N chemical shifts and couplings have been measured for several platinum(II)amine complexes. The ^(15)N chemical shift changes found on coordination of azine-type nitrogens to platinum appear to be related to those that occur on protonation of the same nitrogens. Both the ^(15)N chemical shifts and the one-bond ^(l5)N-^(195)Pt coupling constants depend on the nature of the cis and trans ligands. cis-[Pt(NH_3)_2Cl_2]("cis-platinum") forms a complex with cytidine through N^3. Guanosine becomes bound to platinum of cis- [Pt(NH_3)_2Cl_2] at N7 and at least one other nitrogen. Adenosine appears to bind cis-[Pt(NH_3)_2Cl_2] to at least some degree through N1, N3, N7, and the 6' -NH_2.
Additional Information
© 1982 American Chemical Society. From the Gates and Crellin Laboratories of Chemistry, California Institute of Technology, Pasadena, California 91125. Received February 23, 1982. Contribution No. 6710. Supported by the National Science Foundation and the US. Public Health Service, Research Grant No. GM-11072 from the Division of General Medical Sciences.Additional details
- Eprint ID
- 60759
- Resolver ID
- CaltechAUTHORS:20151005-113555194
- NSF
- GM-11072
- U.S. Public Health Service (USPHS)
- Created
-
2015-10-05Created from EPrint's datestamp field
- Updated
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2021-11-10Created from EPrint's last_modified field
- Other Numbering System Name
- Caltech Gates and Crellin Laboratories
- Other Numbering System Identifier
- 6710