Published August 1948
| public
Journal Article
A Neurospora mutant deficient in the enzymatic synthesis of tryptophan
- Creators
- Mitchell, Herschel K.
- Lein, Joseph
Abstract
Until recently there has been no demonstrated case in Neurospora in which the loss of activity of an essential enzyme could be attributed to gene mutation. It has been assumed from indirect evidence1 that gene mutations do cause such losses and thereby result in "blocks" of essential biochemical reactions. The products of the "blocked" reactions thus become essential growth substances for the mutants. The first success in obtaining direct evidence to support the above assumption has been attained by Wagner and Guirard in studies on the enzymatic synthesis of pantothenic acid by cell-free extracts of Neurospora.
Additional Information
© 1948 American Society for Biochemistry and Molecular Biology. Received for publication, June 23, 1948. This work was supported in part by a grant from the Rockefeller Foundation, and in part under contract with the Office of Naval Research, United States Navy Department. We are indebted to Dr. I. C. Gunsalus for the pyridoxal phosphate used.Additional details
- Eprint ID
- 59397
- Resolver ID
- CaltechAUTHORS:20150811-111645768
- Rockefeller Foundation
- Office of Naval Research (ONR)
- Merck
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2015-08-11Created from EPrint's datestamp field
- Updated
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2019-10-03Created from EPrint's last_modified field