The response to vagusstoff

Abstract

The molecular cloning of all the major components in the transduction pathway described in Otto Loewi's famous experiments on isolated frog hearts' is now complete with the publication of a letter by Kubo et al. on page 802 of this issue. Loewi cannulated two hearts and connected the effluent from heart A to the input of heart B. He then stimulated the vagus nerve to heart A; in agreement with previous experiments, heart A ceased beating for several minutes.

Additional details