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Published June 30, 2004 | Supplemental Material
Journal Article Open

A chondroitin sulfate small molecule that stimulates neuronal growth

Abstract

Chondroitin sulfate glycosaminoglycans are sulfated polysaccharides involved in cell division, neuronal development, and spinal cord injury. Here, we report the synthesis and identification of a chondroitin sulfate tetrasaccharide that stimulates the growth and differentiation of neurons. These studies represent the first, direct investigations into the structure−activity relationships of chondroitin sulfate using homogeneous synthetic molecules and define a tetrasaccharide as a minimal motif required for activity.

Additional Information

© 2004 American Chemical Society. Received March 19, 2004. Publication Date (Web): June 2, 2004. We thank Dr. R. H. Grubbs for the catalyst and helpful discussions and the Biological Imaging Center at Caltech for instrumentation. We also thank J. Chen, J. Ho, B. Ling, and C. Wang for experimental assistance. This research was supported by the Beckman Young Investigator Program, the Human Frontier Science Program, and the Alfred P. Sloan Foundation.

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