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Published January 2004 | Published + Supplemental Material
Journal Article Open

A 'molecular switchboard' - covalent modifications to proteins and their impact on transcription

Abstract

Proteins undergo a remarkable variety of posttranslational modifications, with more than 200 distinct modifications identified to date. Increasing evidence suggests that many proteins bear multiple, distinct modifications, and the ability of one modification to antagonize or synergize the deposition of another can have significant biological consequences. Here, we illustrate the importance of posttranslational modifications within the context of transcriptional regulation, and we offer a perspective on the emerging role of combinatorial networks of modifications. Finally, we discuss the potential for chemical approaches to transform our understanding of the field.

Additional Information

© 2004 The Royal Society of Chemistry. Received 7th October 2003, Accepted 11th November 2003. First published as an Advance Article on the web 2nd December 2003.

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Supplemental Material - b312466e.tiff

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Created:
August 19, 2023
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