Published December 27, 1990
| public
Journal Article
The let-23 gene necessary for Caenorhabditis elegans vulval induction encodes a tyrosine kinase of the EGF receptor subfamily
Abstract
The let-23 gene is required for induction of the Caenorhabditis elegans vulva. It is shown that let-23 encodes a putative tyrosine kinase of the epidermal growth factor receptor subfamily. Thus, let-23 might encode the receptor for the inductive signal required for vulval development. Because let-23 acts upstream of let-60 ras in the vulval determination pathway, the identification of the let-23 product provides support for a link in vivo between tyrosine kinase growth factor receptors and ras proteins in a pathway of cell-type determination.
Additional Information
© 1990 Nature Publishing Group. Received 5 November; accepted 14 November 1990. We thank J. Sulston and A. Coulson (MRC, United Kingdom) for physical mapping of kin-7 and the gifts of cosmid clones, C. Link for the genomic library. R. Barstead for the cDNA library and protocols, R. Waterston for YACs, A. Papp for a mapping strain, J. Kramer and J. Park for mapping information, I Mori, t. Tani, P. Tsoulfas, M. Han and members of our laboratories for suggestions and discussions, and A. Holboke, J. Luxemburg and P. Tzou for technical assistance. This work was supported by US Public Health Service (P.W.S.) and the Ministry of Education, Science and Culture of Japan (Y.O.)Additional details
- Eprint ID
- 57497
- DOI
- 10.1038/348693a0
- Resolver ID
- CaltechAUTHORS:20150513-111306779
- U.S. Public Health Service (USPHS)
- Ministry of Education, Science and Culture (Japan)
- Howard Hughes Medical Institute (HHMI)
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2015-05-13Created from EPrint's datestamp field
- Updated
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2021-11-10Created from EPrint's last_modified field