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Published July 5, 1990 | public
Journal Article

The protein encoded by the Arabidopsis homeotic gene agamous resembles transcription factors

Abstract

Mutations in the homeotic gene agamous of the plant Arabidopsis cause the transformation of the floral sex organs. Cloning and sequence analysis of agamous suggest that it encodes a protein with a high degree of sequence similarity to the DNA-binding region of transcription factors from yeast and humans and to the product of a homeotic gene from Antirrhinum. The agamous gene therefore probably encodes a transcription factor that regulates genes determining stamen and carpel development in wild-type flowers.

Additional Information

© 1990 Nature Publishing Group. Received 24 April; accepted 1 June 1990. We thank S. Kempin, L. Medrano, Y. Hu for technical assistance, L. Huang for help in cDNA library construction, and T. Stearns for help with the protein sequence database search. We also thank U. Vijayraghavan for helpful discussions, and A. van der Bliek, C, Chang, S. Kempin and D. Weigel for critical reading of the manuscript, K.A.F. thanks M.L Christianson for being allowed to experiment on the transformation of intact tissues, and for numerous insightful discussions, while a postdoctoral fellow in Christianson's lab. This work was supported by the NSF and the Lucille P. Markey Charitable Trust (E.M.M.) M.F.Y., H.M. and G.N.D. were supported by the NSF (plant biology), the Helen Hay Whitney Foundation and the NIH, respectively.

Additional details

Created:
August 19, 2023
Modified:
October 23, 2023