Published August 6, 1992
| public
Journal Article
The gene lin-3 encodes an inductive signal for vulval development in C. elegans
- Creators
- Hill, Russell J.
-
Sternberg, Paul W.
Abstract
The lin-3 gene is necessary for induction of the Caenorhabditis elegans vulva by the anchor cell. It encodes a molecule similar to epidermal growth factor and to transforming growth factor-a and acts through the epidermal growth factor receptor homologue let-23. Expression of lin-3 in the anchor cell stimulates vulval induction; lin-3 may encode the vulval inducing signal.
Additional Information
© 1992 Nature Publishing Group. Received 7 May: accepted 25 June 1992. We thank P. Tzou for technical assistance, A. Coulson and J. Sulston for the λ2001 genomic library and cosmids near the lin-3 locus; R. Waterston for YAC clones grids; I. Mori for RW7096; M. Chalfie for TU355; A. Rose and O. Bailie for map data; A. Fire for lacZ expression vectors and protocols; R. Barstead, C. Martin and S. Kim for cDNA libraries; P. Bjorkman. L. Kozar and E. Schwarz for help with sequence analysis; L. Carta and L. Huang for sharing unpublished results; and members of our laboratory, O. Anderson and E. Schwarz for their comments on the manuscript. This work was supported by a USPHS grant and a Searle Scholar Award to P.W.S. P.W.S. is an investigator of the Howard Hughes Medical Institute. R.J.H. was an NSF predoctoral fellow.Additional details
- Eprint ID
- 57457
- DOI
- 10.1038/358470a0
- Resolver ID
- CaltechAUTHORS:20150512-124029795
- U.S. Public Health Service (USPHS)
- Searle Scholars Program
- Howard Hughes Medical Institute (HHMI)
- NSF Predoctoral Fellowship
- Created
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2015-05-12Created from EPrint's datestamp field
- Updated
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2021-11-10Created from EPrint's last_modified field