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Published September 3, 1992 | public
Journal Article

Reagents for the site-specific cleavage of megabase DNA

Abstract

The physical mapping of chromosomes will be facilitated by methods of breaking large DNA into manageable fragments, or cutting uniquely at genetic markers of interest. Key issues in the design of sequence-specific DNA cleaving reagents are the specificity of binding, the number of different sequences that can be targeted and the cleavage yield.

Additional Information

© 1992 Nature Publishing Group.

Additional details

Created:
August 20, 2023
Modified:
October 23, 2023