Recent proteomic advances in developmental, regeneration, and cancer governing signaling pathways
- Creators
- Franco, Catarina
- Hess, Sonja
Abstract
Embryonic development, adult tissue repair, and cancer share a number of common regulating pathways. The basic processes that govern the events that induce mesenchymal properties in epithelial cells—a process known as epithelial-mesenchymal transition—are central for embryonic development, and can be resumed in adults either during wound healing or tissue regeneration. A misregulation of these pathways is involved in pathological situations, such as tissue fibrosis and cancer. Proteomic approaches have emerged as promising tools to better understand the signaling pathways that govern these complex biological processes. This review focuses on the recent proteomic-based contributions to better understand the modulation of transforming growth factor-beta (TGF-β), wingless-type MMTV integration site family (Wnt), Notch and Receptor tyrosine kinase (RTK) signaling pathways. New advances include the description of new protein interactions, the formation of new protein complexes or the description on how some PTMs are regulating these pathways. Understanding protein interactions and the tempo-spatial modulation of these pathways might lead us to interesting research quests in cancer, embryonic development or even on improving adult tissue regeneration capabilities.
Additional Information
© 2014 Wiley-VCH Verlag GmbH & Co. KGaA, Weinheim. Received: July 31, 2014; Revised: September 16, 2014; Accepted: October 9, 2014; Article first published online: 23 Dec. 2014. This work was enabled through the following funding sources: Gordon and Betty Moore Foundation through grant GBMF775 and the Beckman Institute; (SH) Fulbright, PROLAB (ASBMB) through a Wood-Whelan fellowship from IUBMB and from Fundação para a Ciência e Tecnologia (Lisbon, Portugal) with both a project grant (PTDC/MAR-BIO/2174/2012) and postdoctoral fellowship to C.F. (SFRH/BPD/79271/2011).Additional details
- Eprint ID
- 57327
- Resolver ID
- CaltechAUTHORS:20150507-095736092
- GBMF775
- Gordon and Betty Moore Foundation
- Caltech Beckman Institute
- Fulbright Foundation
- PROLAB (ASBMB)
- PTDC/MAR-BIO/2174/2012
- Fundação para a Ciência e Tecnologia (FCT)
- SFRH/BPD/79271/2011
- Fundação para a Ciência e Tecnologia (FCT)
- Created
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2015-05-08Created from EPrint's datestamp field
- Updated
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2021-11-10Created from EPrint's last_modified field