Welcome to the new version of CaltechAUTHORS. Login is currently restricted to library staff. If you notice any issues, please email coda@library.caltech.edu
Published December 1984 | public
Journal Article

Studies of Protein Function by Various Mutagenic Strategies: β-Lactamase

Abstract

Structure unambiguously determines the function of proteins; the linear amino acid sequence in turn dictates three-dimensional structure. Important insights into the molecular origins of the functional behavior of a particular protein become possible if one can alter in prescribed ways the structure of that protein, thereby allowing one to undertake structure-function studies of the type that have a long history of success in organic and pharmaceutical chemistry. Changes in the structure of a protein can be most expeditiously accomplished by appropriate changes in the base sequence of the DNA encoding that protein.

Additional Information

© 1984 John Wiley & Sons, Inc. This work was supported by the following grants: NIH GM 16424 and ONR N00014-83-K-0487.

Additional details

Created:
August 19, 2023
Modified:
October 23, 2023