Published 1984
| public
Journal Article
Studies on C3a_(hu) Binding to Human Eosinophils: Characterization of Binding
Abstract
C3a purified to chemical homogeneity from human serum binds preferentially to human eosinophils > neutrophils. Little or no binding is found with human platelets. Maximum binding to eosinophils at 37 °C occurs within 15 min. Dilution of ^(125)I-C3a by either cold C3a or washing away unbound ^(125)I-C3a and reincubating at 37 °C reveals a T_(1/2) of ∼30 min. C3a_(desArg) neither binds to eosinophils nor inhibits the binding of ^(125)I-C3a. The binding of C3a to human eosinophils may reflect a physiologic role of C3a in eosinophil motility or function.
Additional Information
© 1984 S. Karger AG, Basel. Received: July 11, 1983. We are grateful to Lucette Ghekiere for her technical assistance and to Marijo Dowling for secretarial skills. These studies were supported by Southern California Permanente Medical Group and Kaiser Foundation Hospitals Grant No. 17.Additional details
- Eprint ID
- 57234
- DOI
- 10.1159/000233535
- Resolver ID
- CaltechAUTHORS:20150505-115820659
- Southern California Permanente Medical Group
- 17
- Kaiser Foundation Hospitals Grant
- Created
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2015-05-06Created from EPrint's datestamp field
- Updated
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2021-11-10Created from EPrint's last_modified field