Gene Expression in Differentiating and Transdifferentiating Neural Crest Cells

Creators: Anderson, David J.; Stein, R.; Axel, R.

Abstract

The neural crest is a transient population of cells that detach from the top of the neural tube and then disperse throughout the embryo giving rise to the peripheral nervous system, melanocytes, and the adrenal medulla, as well as a diverse array of other cell types. Transplantation experiments suggest that most premigratory cells throughout the neural crest have the same developmental potential, regardless of their actual fate (LeDouarin 1982; Weston 1982.) Thus, the environment encountered by crest cells during or after migration appears to be critical in determining their final phenotype.

Additional Information

© 1985 Cold Spring Harbor Laboratory Press. The Authors acknowledge that six months after the full-issue publication date, the Article will be distributed under a Creative Commons CC-BY-NC License (Attribution-NonCommercial 4.0 International License, http://creativecommons.org/licenses/by-nc/4.0/) We are grateful to Drs. Allison Doupe, Paul Patterson, Tom Jessell, and Story Landis for their helpful suggestions. We also thank Drs. Robert Angerer, Jim Roberts, and Eva Dworkin for providing detailed procedures for in situ hybridization, and Dr. John Pintar for providing some of the embryo sections used in this study and helping us to interpret the embryonic anatomy. This work was supported by the Howard Hughes Medical Institute, and a fellowship to D.J.A. from the Helen Hay Whitney Foundation.

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