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Published August 2003 | Supplemental Material
Journal Article Open

Technicolour transgenics: Imaging tools for functional genomics in the mouse

Abstract

Over the past decade, a battery of powerful tools that encompass forward and reverse genetic approaches have been developed to dissect the molecular and cellular processes that regulate development and disease. The advent of genetically-encoded fluorescent proteins that are expressed in wild type and mutant mice, together with advances in imaging technology, make it possible to study these biological processes in many dimensions. Importantly, these technologies allow direct visual access to complex events as they happen in their native environment, which provides greater insights into mammalian biology than ever before.

Additional Information

© 2003 Nature Publishing Group. We thank F. Costantini, L. Jones and J. Lichtman for generously providing figures. We apologize to the authors of many important findings and strains of mice that are not discussed here owing to space limitations. Our work is supported by grants from the National Institutes of Health, National Science Foundation and Muscular Dystrophy Association. A.-K.H. is a fellow of the American Heart Association.

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Created:
August 19, 2023
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October 23, 2023