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Published March 2001 | public
Journal Article

Molecular physiology of P2X receptors and ATP signalling at synapses

Abstract

ATP is found in every cell, where it is a major source of energy. But in the nervous system, ATP also has additional actions, which include its role in fast synaptic transmission and modulation. Here I discuss the 'fast' actions of ATP at synapses, the properties of the receptors that are activated by ATP and the physiology of ATP signalling, with emphasis on its role in pain processing.

Additional Information

© 2001 Macmillan Magazines Ltd. While at Caltech, B.S.K. was supported by a Wellcome Trust (UK) International Prize Travelling Research Fellowship and Roche Bioscience (Palo Alto). Many thanks to Cesar Labarca for comments on the paper and to Henry A. Lester for encouragement.

Additional details

Created:
August 19, 2023
Modified:
October 23, 2023