Welcome to the new version of CaltechAUTHORS. Login is currently restricted to library staff. If you notice any issues, please email coda@library.caltech.edu
Published November 16, 1984 | public
Journal Article

Homologies between Signal Transducing G Proteins and ras Gene Products

Abstract

The guanosine triphosphate-binding proteins (G proteins) found in a variety of tissues transduce signals generated by ligand binding to cell surface receptors into changes in intracellular metabolism. Amino acid sequences of peptides prepared by partial proteolysis of the alpha subunit of a bovine brain G protein and the alpha subunit of rod outer-segment transducin were determined. The two proteins show regions of sequence identity as well as regions of diversity. A portion of the amino-terminal peptide sequence of each protein is highly homologous with the corresponding region in the ras protein (a protooncogene product). These similarities suggest that G proteins and ras proteins may have analogous functions.

Additional Information

© 1984 American Association for the Advancement of Science. 20 September 1984; Accepted 16 October 1984. We thank Michael Lochrie for helpful discussions and Rosemary Hopkins for technical assistance. Supported by NIH grant NS 18153 (A.G.G.), American Cancer Society grant BC 240 (A.G,G.), NIH fellowship GM 09731-02 (J.D.R.), and NSF grant PCM 8411039 (M.I.S.).

Additional details

Created:
August 19, 2023
Modified:
October 20, 2023