Published May 27, 1983
| public
Journal Article
Human Platelet-Derived Growth Factor (PDGF): Amino-Terminal Amino Acid Sequence
Abstract
Human platelet-derived growth factor (PDGF) obtained from outdated human platelets was subjected to amino-terminal amino acid sequence analysis by automated Edman degradation. Despite the apparent presence of limited proteolytic degradation of the protein derived from this method, the sequence analysis reveals two primary peptide sequences and suggests that active PDGF is composed of two, possibly homologous, peptides linked by a disulfide bond or bonds.
Additional Information
© 1983 American Association for the Advancement of Science. 5 January 1983; revised 17 March 1983. Supported by the Weingart Foundation, National Cancer Institute grant CA30101, and a grant from the Council for Tobacco Research, USA, Inc. We thank P. Moran, R. Siraco, and K. Burke-Howie for assistance in purification and cell culture assays of PDGF and the American Red Cross Blood Services, Northeast Region, for the supply of clinically outdated human platelets.Additional details
- Eprint ID
- 54408
- Resolver ID
- CaltechAUTHORS:20150205-090218284
- Weingart Foundation
- CA30101
- National Cancer Institute
- Council for Tobacco Research
- Created
-
2015-02-05Created from EPrint's datestamp field
- Updated
-
2021-11-10Created from EPrint's last_modified field