Published July 1, 1983
| public
Journal Article
Molecular Genetics of the Bithorax Complex in Drosophila melanogaster
Abstract
The bithorax complex in Drosophila melanogaster is a cluster of homeotic genes that specify developmental pathways for many of the body segments of the fly. The DNA of the bithorax complex has been isolated, and a region of 195,000 base pairs that covers the left half of the complex is described here. The lesions associated with many of the bithorax complex mutants have been identified, and most are due to DNA rearrangements. Most of the spontaneous mutants have insertions of a particular mobile element named "gypsy." This element affects the functions of sequences removed from the site of insertion. Mutant lesions for a given phenotypic class are distributed over large DNA distances of up to 73,000 base pairs.
Additional Information
© 1983 American Association for the Advancement of Science. 17 March 1983; Revised 11 May 1983. We thank R. Saint for providing subclones of many bithorax restriction fragments., R. Paro for providing clones from the TE77 insertion site, K. Wepsic for care of mutant stocks, and W. Harpain for his generous gift of half-pint milk bottles. This work was supported by NIH grants to W.B., D.S.H., and E.B.L. and by an NSF grant to D.S.H. with additional funding from a Helen Hay Whitney Foundation fellowship (W.B.), a Damon Runyon fellowship (M.A.), Swiss National Foundation fellowships (F.K. and P.S.), and a National Science Foundation predoctoral fellowship (M.P.).Additional details
- Eprint ID
- 54219
- DOI
- 10.1126/science.221.4605.23
- Resolver ID
- CaltechAUTHORS:20150129-085516108
- NIH
- NSF Predoctoral Fellowship
- Helen Hay Whitney Foundation
- Damon Runyon Cancer Research Foundation
- Swiss National Foundation
- Created
-
2015-01-29Created from EPrint's datestamp field
- Updated
-
2023-10-20Created from EPrint's last_modified field