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Published September 6, 1996 | public
Journal Article

A Requirement for Local Protein Synthesis in Neurotrophin-Induced Hippocampal Synaptic Plasticity

Abstract

Two neurotrophic factors, brain-derived neurotrophic factor (BDNF) and neurotrophin-3 (NT-3), are able to produce a long-lasting enhancement of synaptic transmission in the hippocampus. Unlike other forms of plasticity, neurotrophin-induced plasticity exhibited an immediate requirement for protein synthesis. Plasticity in rat hippocampal slices in which the synaptic neuropil was isolated from the principal cell bodies also required early protein synthesis. Thus, the neurotrophins may stimulate the synthesis of proteins in either axonal or dendritic compartments, allowing synapses to exert local control over the complement of proteins expressed at individual synaptic sites.

Additional Information

© 1996 American Association for the Advancement of Science. 20 May 1996; accepted 16 July 1996. We thank J. Miller and Amgen for supplying BDNF and NT-3, and Caltech faculty and the Schuman lab for helpful discussions and comments. Supported by funds from the Sloan Foundation, John Merck Fund, and Pew Charitable Trusts to E.M.S.

Additional details

Created:
August 19, 2023
Modified:
October 19, 2023