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Published July 12, 2004 | Supplemental Material
Journal Article Open

Alternative Translations of a Single RNA Message: An Identity Switch of (2S,3R)-4,4,4-Trifluorovaline between Valine and Isoleucine Codons

Abstract

Changed in translation: Bacterial expression hosts can be engineered so that a single RNA message can be read in different ways depending on the relative rates of competing aminoacylation reactions. The (2S,3R)-4,4,4-trifluorovaline can be assigned either to isoleucine or to valine codons according to whether the bacterial host overexpresses the isoleucyl- or the valyl-tRNA synthetase (IleRS and ValRS, respectively; see scheme).

Additional Information

© 2004 Wiley VCH. Issue published online: 7 JUL 2004. Article first published online: 21 JUN 2004. Manuscript Received: 17 FEB 2004. This work was supported by the National Institutes of Health (grant nos. GM65500 and GM62523), by a National Sciences Foundation CAREER award (CHE-0236846), and by the National Science Foundation Center for Science and Engineering of Materials at the California Institute of Technology.

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August 22, 2023
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