Published June 21, 1991
| public
Journal Article
Toward a Science of Metabolic Engineering
- Creators
- Bailey, James E.
Abstract
Application of recombinant DNA methods to restructure metabolic networks can improve production of metabolite and protein products by altering pathway distributions and rates. Recruitment of heterologous proteins enables extension of existing pathways to obtain new chemical products, alter posttranslational protein processing, and degrade recalcitrant wastes. Although some of the experimental and mathematical tools required for rational metabolic engineering are available, complex cellular responses to genetic perturbations can complicate predictive design.
Additional Information
© 1991 American Association for the Advancement of Science. Supported by NSF and by the Catalysis and Biocatalysis Program of the Advanced Industrial Concepts Division of the U.S. Department of Energy. Advice and assistance in the preparation of this paper were provided by D. S. Clark, B. D. Ensley, T. Hashimoto, R. J. Kaufman, C. Khosla, R. A. Lazarus, A. J. Sinskey, K. N. Timmis, and colleagues at the California Institute of Technology.Additional details
- Eprint ID
- 53705
- DOI
- 10.1126/science.2047876
- Resolver ID
- CaltechAUTHORS:20150114-105857007
- NSF
- Department of Energy (DOE)
- Created
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2015-01-14Created from EPrint's datestamp field
- Updated
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2021-11-10Created from EPrint's last_modified field