Published October 4, 1991
| public
Journal Article
Large-Scale and Automated DNA Sequence Determination
- Creators
- Hunkapiller, T.
- Kaiser, R. J.
- Koop, B. F.
-
Hood, L.
Abstract
DNA sequence analysis is a multistage process that includes the preparation of DNA, its fragmentation and base analysis, and the interpretation of the resulting sequence information. New technological advances have led to the automation of certain steps in this process and have raised the possibility of large-scale DNA sequencing efforts in the near future [for example, 1 million base pairs (Mb) per year]. New sequencing methodologies, fully automated instrumentation, and improvements in sequencing-related computational resources may render genome-size sequencing projects (100 Mb or larger) feasible during the next 5 to 10 years.
Additional Information
© 1991 American Association for the Advancement of Science. 4 October 1991. We thank the NSF, DOE, NIH, and Alfred P. Sloan Foundation for support, Drs. D. Nickerson and J. R. Yates for careful reading of the manuscript, and K. McCarthy for help in preparing the manuscript.Additional details
- Eprint ID
- 53675
- DOI
- 10.1126/science.1925562
- Resolver ID
- CaltechAUTHORS:20150114-091754010
- NSF
- Department of Energy (DOE)
- NIH
- Alfred P. Sloan Foundation
- Created
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2015-01-14Created from EPrint's datestamp field
- Updated
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2021-11-10Created from EPrint's last_modified field