Published February 4, 1994
| public
Journal Article
Magnetic resonance microscopy of embryonic cell lineages and movements
- Creators
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Jacobs, Russell E.
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Fraser, Scott E.
Abstract
Key events in vertebrate embryogenesis are difficult to observe in many species. High-resolution magnetic resonance imaging was used to follow cell movements and lineages in developing frog embryos. A single cell was injected at the 16-cell stage with a contrast agent, based on the gadolinium chelate gadolinium-diethylenetriamine pentaacetic acid-dextran. The labeled progeny cells could be followed uniquely in three-dimensional magnetic resonance images, acquired from the embryo over several days. The results show that external ectodermal and internal mesodermal tissues extend at different rates during amphibian gastrulation and neurulation.
Additional Information
© 1994 American Association for the Advancement of Science. 27 August 1993; Accepted 24 November 1993. We thank Z. H. Cho, C. B. Ahn, and S. Juh for assistance in the initial phases of this project; and J. Shih, A. Collazo, and J. Ivins for comments on the manuscript. Supported by National Institutes of Health grant HD 25390, the Baxter Foundation, and a gift from the Monsanto-Searle Company.Additional details
- Eprint ID
- 53523
- DOI
- 10.1126/science.7508143
- Resolver ID
- CaltechAUTHORS:20150109-151941399
- HD 25390
- NIH
- Baxter Foundation
- Monsanto-Searle Company
- Created
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2015-01-12Created from EPrint's datestamp field
- Updated
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2021-11-10Created from EPrint's last_modified field