Surface functionalized mesoporous silica nanoparticles as an effective carrier for epirubicin delivery to cancer cells
Abstract
Recent studies with inorganic nanoparticles modified with functional groups have demonstrated improvement in drug delivery into cancer cells. In the present study, we prepared, characterized, and evaluated mesoporous silica nanoparticles (MSNs) as carriers for epirubicin hydrochloride (EPI) in order to improve the antitumor efficacy of this drug. MSNs were prepared and functionalized with phosphonate, polyethylene glycol (PEG) and polyethylenimine–polyethylene glycol (PEI–PEG) groups. Different nanoparticulate formulations were loaded with EPI. The in vitro cytotoxicity and the in vivo antitumor efficacy of MSNs containing EPI were evaluated versus free EPI. The EPI release from nanoparticles was shown to be pH-dependent. The size of MSNs functionalized with polyethyleneimine-polyethylene glycol (MSN–PEI–PEG) was 123.8 ± 4.8 nm. This formulation showed the best antitumor effects at an EPI dose of 9 mg/kg in C-26 colon carcinoma model. The biodistribution results proved that MSN–PEI–PEG–EPI had a higher tumor accumulation compared to free EPI, 3 h after drug administration. The results indicated that this formulation could be effective nanocarriers for anti-tumor therapies.
Additional Information
© 2014 Elsevier B.V. Received 13 October 2014, Accepted 7 December 2014, Available online 13 December 2014. The results described in this paper are extracted from Mohammad Yahya Hanafi-Bojd's Ph.D. thesis. This study was supported by a Grant from the Vice Chancellor for Research of Mashhad University of Medical Science, Mashhad, Iran.Additional details
- Eprint ID
- 53097
- Resolver ID
- CaltechAUTHORS:20141222-130918789
- Mashhad University of Medical Science (Iran)
- Created
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2014-12-23Created from EPrint's datestamp field
- Updated
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2021-11-10Created from EPrint's last_modified field