Published August 25, 1995
| public
Journal Article
Similarity of sli-1, a regulator of vulval development in C. elegans, to the mammalian proto-oncogene c-cbl
Abstract
Vulval induction during Caenorhabditis elegans development is mediated by LET-23, a homolog of the mammalian epidermal growth factor receptor tyrosine kinase. The sli-1 gene is a negative regulator of LET-23 and is shown here to encode a protein similar to c-Cbl, a mammalian proto-oncoprotein. SLI-1 and c-Cbl share approximately 55 percent amino acid identity over a stretch of 390 residues, which includes a C_3HC_4 zinc-binding motif known as the RING finger, and multiple consensus binding sites for Src homology 3 (SH3) domains. SLI-1 and c-Cbl may define a new class of proteins that modify receptor tyrosine kinase-mediated signal transduction.
Additional Information
© 1995 American Association for the Advancement of Science. Received 13 April 1995; accepted 2 June 1995. We thank G. Lesa, N. Hopper, and R. Sommer for comments on the manuscript; G. Medina and other members of the Sternberg laboratory for technical assistance; J. Mendel for pJMG3BP.11; and W. Langdon for discussions. Supported by a grant from the U.S. Public Health Service to P.W.S., who is an investigator with the Howard Hughes Medical Institute.Additional details
- Eprint ID
- 52632
- DOI
- 10.1126/science.7652556
- Resolver ID
- CaltechAUTHORS:20141212-124138923
- U.S. Public Health Service (USPHS)
- Howard Hughes Medical Institute (HHMI)
- Created
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2014-12-12Created from EPrint's datestamp field
- Updated
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2021-11-10Created from EPrint's last_modified field