Organization of an echinoderm Hox gene cluster
Abstract
The Strongylocentrotus purpuratus genome contains a single ten-gene Hox complex >0.5 megabase in length. This complex was isolated on overlapping bacterial artificial chromosome and P1 artificial chromosome genomic recombinants by using probes for individual genes and by genomic walking. Echinoderm Hox genes of Paralog Groups (PG) 1 and 2 are reported. The cluster includes genes representing all paralog groups of vertebrate Hox clusters, except that there is a single gene of the PG4–5 types and only three genes of the PG9–12 types. The echinoderm Hox gene cluster is essentially similar to those of the bilaterally organized chordates, despite the radically altered pentameral body plans of these animals.
Additional Information
© 1999 The National Academy of Sciences. Contributed by Eric H. Davidson, December 18, 1998. It is a pleasure to acknowledge the expert assistance of Dr. Kevin Peterson of this laboratory in the phylogenetic analyses of Hox gene sequences referred to throughout this work and also for helpful critical comments on the manuscript. We are extremely grateful to Drs. Ellen Popodi (Indiana University), Robert Maxson (University of Southern California), Michael Murtha (Yale University), and Giovanni Spinnelli (University of Palermo) for providing us with Hox probes from various sea urchin species. We thank Valeria Mancino for help with pulsed-field electrophoresis. Drs. Chris Amemiya and Pieter de Jong were extremely helpful in providing us with their PAC and BAC vectors, respectively. This work was supported by the Stowers Institute for Medical Research and by a grant from the National Institute of Child Health and Human Development. J.P.R. was supported by a National Institutes of Health Training Grant (HD-07257). The publication costs of this article were defrayed in part by page charge payment. This article must therefore be hereby marked ''advertisement'' in accordance with 18 U.S.C. §1734 solely to indicate this fact.Attached Files
Published - PNAS-1999-Martinez-1469-74.pdf
Files
| Name | Size | Download all |
|---|---|---|
|
md5:f45c921d169dcf79bbaf852d71f608e3
|
161.5 kB | Preview Download |
Additional details
- PMCID
- PMC15486
- Eprint ID
- 52164
- Resolver ID
- CaltechAUTHORS:20141125-151903783
- Stowers Institute for Medical Research
- National Institute of Child Health and Human Development
- HD-07257
- NIH Training Grant
- Created
-
2014-11-26Created from EPrint's datestamp field
- Updated
-
2021-11-10Created from EPrint's last_modified field